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C-Myc supports polyploidy and prevents senescence in the murine placenta [scRNA-Seq]

ABSTRACT: Placenta is essential for reproductive success and placental abnormalities are the leading cause of low birth weight and preterm birth. The placenta includes polyploid cells that are crucial for its function. Polyploidy occurs broadly in nature but the regulators that enable polyploidy to arise in a spatiotemporally regulated manner in the placenta are unknown. We used scRNA seq to understand molecular regulators of polyploidy.

ORGANISM(S): Mus musculus

PROVIDER: GSE215381 | GEO | 2023/05/12

REPOSITORIES: GEO

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