Identify and eradicate leukemia stem cells in T-cell acute lymphoblastic leukemia by PD-1 therapy

ABSTRACT: To investigate the characteristics of PD-1+ LSCs in T-ALL, we purified PD-1+ and PD-1– T-ALL cells from the bone marrow (femur and tibia) of T-ALL mice, Pten null T-ALL mice, or PDX recipients. RNA sequencing was performed to explore the differential gene expression and pathway enrichment of PD-1+ LSCs in T-ALL.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE215392 | GEO | 2022/12/13

REPOSITORIES: GEO