Single cell RNA sequencing on PyMT mammary gland primary tumor and lung metastases

ABSTRACT: Using scRNA-seq of the PyMT/GPx2 KD versus the PyMT control tumor model, we identified an overlap in cell clustering involving six luminal-like clusters and one basal/mesenchymal-like cluster (cluster 3). Similarly, scRNA-seq of lung metastases derived from the GPx2 KD tumor unraveled several luminal-like clusters and one mesenchymal-like cluster (M-cluster) which was highly homologous to primary tumor cluster 3.

ORGANISM(S): Mus musculus

PROVIDER: GSE215394 | GEO | 2023/04/29

REPOSITORIES: GEO