Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cuspal shape alterations by Bmp4 directing cell proliferation and apoptosis

ABSTRACT: To investigate the involvement of cuspal patterning with cell proliferation and apoptotic pathway, we compared gene expression profiling between mouse and gerbil tooth germs.

ORGANISM(S): Mus musculus Meriones unguiculatus

PROVIDER: GSE215404 | GEO | 2022/10/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Cuspal shape alterations by Bmp4 directing cell proliferation and apoptosis

Project description:Cuspal shape alterations by Bmp4 directing cell proliferation and apoptosis

| PRJNA890222 | ENA

Expression data at 24 hours after the blocking of Shh signaling in tooth germs at embryonic day 14

Project description:The genetic mechanism governing the spatial patterning of teeth still remains to be elucidated. Sonic hedgehog (Shh) is one of key signaling molecules involved in the spatial patterning of teeth. By utilizing maternal transfer of 5E1 (an IgG1 monoclonal antibody against Shh protein) through the placenta to block Shh signaling, we investigated the changes in tooth patterning and in gene expression. We used microarrays to detect specific genes related with Shh signaling in tooth germs and identified some specific genes up- or down-regulated after blocking of Shh signaling activity. Gene-chip expression analysis was performed with RNA from mandibular tooth germs from embryos of pregnant mice at one day after injection of 5E1 (an IgG1 monoclonal antibody against Shh protein; number of replicates =2), 40-1a (an IgG1 monoclonal antibody against β-galactosidase; number of replicates=2), cyclopamine (a specific Smo antagonist; number of replicates=2) or PBS (Phosphate buffered saline; number of replicates=2), using a Affymetrix mouse gene microarray.

2011-02-22 | E-GEOD-27429 | biostudies-arrayexpress

Expression data at 24 hours after the blocking of Shh signaling in tooth germs at embryonic day 14

2011-02-22 | GSE27429 | GEO

miRNA expression data in tooth germs at embryonic day 11, 12, 14, and 16

Project description:miRNAs are not well known their expression and function in tooth development. To identify the miRNAs expression during tooth development, tooth germs were dissected from the initiation bud, cap and bell stages. miRNA-chip expression analysis was performed with RNAs of the molar tooth germs from embryos of pregnant mice at emrbryonic day 11, 12, 14, and 16, using Agilent's miRNA microarray.

2014-01-09 | E-GEOD-53903 | biostudies-arrayexpress

E14 mouse molar tooth germs cultured with/without TCDD

Project description:Dioxins are ubiquitous environmental poisons that are developmentally toxic. Exposure of mouse E14 tooth germs to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to reduced tooth size and deformation of cuspal morphology implying the induction of a variety of biological responses on both cellular and molecular levels. To verify such responses at the gene level, mouse embryonic cap staged tooth germs were cultured for 24 h with/without 1 µM TCDD. Keywords: tissue culture, exposure to TCDD, tooth development

2006-08-19 | GSE4873 | GEO

miRNA expression data in tooth germs at embryonic day 11, 12, 14, and 16

2014-01-09 | GSE53903 | GEO

Expression data in the Cap Stage of the Human Embryonic Tooth Germ

Project description:Numerous genes that play important regulative roles during tooth development in mice have been identified. However, very little is known about gene expression and function in human odontogenesis. We used microarrays to detail the global programme of gene expression underlying tooth development and identified distinct classes of up-regulated genes during in the tooth germs. Tooth germs of molar, incisor, and canine at the cap stage were dissected, respectively, from 12-week-old human embryonic oral cavity for RNA extraction and hybridization on Affymetrix microarrays. We sought to screen for the genes that are strongly expressed in the dental tissues and analysis if these genes related to mammalian tooth development and tooth abnormalities.

2015-04-01 | E-GEOD-48150 | biostudies-arrayexpress

Next Generation Sequencing Identifies Hoxa1 and Hoxc13 as Downstream Targets of Yap in Mouse Epithelial Tissues

Project description:The goals of this study are to identify in vivo downstream targets of Yap through NGS-derived tooth germ transcriptome profiling. The mRNA profiles of wild-type, Yap conditional knockout (CKO) and YAP transgenic (Tg) mouse tooth germs at embryonic day 14.5 were generated by deep sequencing using Illumina Hiseq2000. The sequence reads that passed quality filters were analyzed at the transcript isoform level via DNAnexus. The validation was performed through qRT–PCR and in situ hybrydization. A set of Hox genes were differentially expression in Yap CKO and YAP Tg mouse tooth germs, demonstating concurrent expression changes with Yap transcripts. This study provides a platform to systematically identify in vivo downstream targets of genes of interest. The mRNA profiles of wild type, Yap CKO and YAP Tg mouse tooth germs at embryonic day 14.5 were generated by deep sequencing using Illumina Hiseq.

2015-02-21 | E-GEOD-65524 | biostudies-arrayexpress

Expression data in the Cap Stage of the Human Embryonic Tooth Germ

2015-04-01 | GSE48150 | GEO

Transcription profiling of tooth germs from mouse fetuses and embryos

Project description:Study of changes in gene expression in mouse tooth germs between E15.5 and 21.5dpc

2007-04-01 | E-MEXP-947 | biostudies-arrayexpress