Paternal DCHP exposure on F1 male liver transcriptome

ABSTRACT: Purpose: To investigate the effects of DCHP expoure on F1 male hepatic metabolic disorders Methods: 8 week male WT mice were exposed to DCHP by oral gavage for 4 weeks, 3 week old F1 male mice were fed with HFD for 9 weeks, glucose and insulin tolerant tests were performed at 10-11 week old, liver RNA was isolated for further transcriptome analysis Results: Mice from DCHP exposure sires displayed glucose/insulin resistant phenotype, together with upregulation in inflammatoy related genes in the liver

ORGANISM(S): Mus musculus

PROVIDER: GSE215806 | GEO | 2023/05/24

REPOSITORIES: GEO