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Comprehensive multi-omics analysis of microbiome, metabolome, and host genome in right- and left-sided colon cancer

ABSTRACT: There are distinct interactions among microbial compositions, metabolites, and host genomes in RCC and LCC as revealed by multi-omics analysis, which brings a new dimension to understanding the role of gut microbiota in tumorigenesis of RCC and LCC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE216022 | GEO | 2023/10/31

REPOSITORIES: GEO

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Comparative analysis of clonal evolution among patients with right-sided colon cancer, left-sided colon cancer and rectal cancer

Project description:Tumor multi-region sequencing reveals clonal evolution which play a key role in progression and metastases of the tumor. However, the comparative analysis among right-sided colon cancer (RCC), left-sided colon cancer (LCC) and rectal cancer (RC) patients as well as the study of lymph node metastasis (LN) with extranodal tumor deposits (ENTD) from evolutionary perspective remain unknown. In this prospective study, we recruited 68 CRC patients with RCC (18), LCC (20) and RC (30). We performed high-depth whole exome sequencing (WES) of 206 tumor regions including primary tumors, LN and ENTD samples. We identified that evolution pattern of LCC and RC was more complex and divergent than RCC, suggesting evolutionary diversity in the initiation and progression of LCC and RC. Genetic and evolutionary evidences found that ENTD was a distinct entity from LN and evolved later. In conclusion, our study showed differences in clonal evolution between RCC with LCC and RC.

2020-11-23 | PRJEB40010 | EVA