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Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis [scRNA-Seq]

ABSTRACT: Single cell RNAseq of control (Ctl) and ERG and FLI1 transduced human MSCs

ORGANISM(S): Homo sapiens

PROVIDER: GSE216111 | GEO | 2022/10/20

REPOSITORIES: GEO

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Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis II

Project description:Bulk RNAseq of human donor MSCs control and with ERG/FLI1 overexpressed

2022-10-17 | GSE213549 | GEO

Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis I

Project description:Bulk RNA-seq of adult liver endothelial cells after 12 days of Fli1 + Erg knockout and control

2022-10-17 | GSE210118 | GEO

Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis [Brain_InVitro_RNAseq]

Project description:Bulk RNAseq of mouse in vitro brain samples either control or Erg and Fli1 double knocked out.

2022-10-17 | GSE215860 | GEO

Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis [Liver_InVivo_ATACseq]

Project description:Bulk ATACseq of mouse in vivo liver vascular Endothelial samples either control or Erg and Fli1 knock out.

2022-10-17 | GSE215864 | GEO

Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis [Liver_InVivo_D7_RNAseq ]

Project description:Bulk RNA-seq of mouse in vivo liver samples from either control or Erg and Fli1 double knocked out.

2022-10-17 | GSE215862 | GEO

Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis [ECs_InVivo_D10_RNAseq]

Project description:Bulk RNA-seq of mouse in vivo liver samples from either control or Erg and Fli1 double knocked out.

2022-10-17 | GSE215863 | GEO

Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis [Liver_IL1B_TNFA_RNAseq]

Project description:Bulk RNA-seq of mouse in in vitro samples from either control or Erg and Fli1 knock out with or without additional treatment of Il1b + Tnfa

2022-10-17 | GSE215861 | GEO

Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-17 | GSE210119 | GEO

SOX7 and ETS factors regulate an endothelial transcriptional program during vascular development (DamID)

Project description:Vascular development involves complex changes in gene expression necessary to dictate the behaviour of differentiating endothelial cells within the emerging vascular network. However, the transcriptional programs regulating vascular development are poorly understood. Here we use a DamID approach to profile for the first time the global DNA binding pattern of SOX7, FLI1 and ERG in endothelial precursor cells. We uncover that SOX7, FLI1 and ERG bind together at endothelial specific regulatory regions to drive a transcriptional program important for vascular development.

2017-11-25 | GSE63645 | GEO

A functional liaison between E2F and the aberrant ETS oncogene EWS/FLI1 in Ewing's sarcoma

Project description:Translocations of ETS transcription factors are driver mutations in diverse cancers. We investigated the genomic network of the ETS fusion EWS/FLI1 in Ewing's sarcoma (ESFT) as a model of ETS-driven tumorigenesis. ChIP-Seq and transcriptional analysis identified E2F3 as a principle co-factor of EWSFLI1 defining functionally distinct gene sets. While EWS/FLI1 binding independent of E2F3 predominantly associated with repressed differentiation genes, significant co-localization with E2F3 was discovered at proximal promoters of activated growth-related genes. Thus, EWS/FLI1 promotes oncogenesis by simultaneously perturbing differentiation state and augmenting the expression of genes co-regulated by E2F3. Integration of additional E2F3 and ERG localization data from prostate cancer containing TMPRSS2/ERG verified that the ETS-E2F module is also found in prostate cancer and may be of general relevance to ETS driven cancers. Timecourse with 6 timepoints of a doxicyclin inducible EWS-FLI1 knockdown in the A673 Ewing's Sarcoma celline

2013-07-01 | E-GEOD-27524 | biostudies-arrayexpress

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