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Levofloxacin induces the downexpression of inflammation-related transcriptome in the gut of spondyloarthritis DBA/1 mice.

ABSTRACT: Gene expression profiles in the gut of DBA/1 mice whit spontaneus arthritis and treated with levofloxacion vs. those who were not received levofloxacin were compared. Levofloxacin induced the downexpression of inflammation-related genes and signaling pathways.

ORGANISM(S): Mus musculus

PROVIDER: GSE216174 | GEO | 2022/10/22

REPOSITORIES: GEO

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Levofloxacin induces the downexpression of inflammation-related transcriptome in the spine of spondyloarthritis DBA/1 mice.

Project description:Gene expression profiles in the spine of DBA/1 mice whit spontaneus arthritis and treated with levofloxacion vs. those who were not received levofloxacin were compared. Levofloxacin induced the downexpression of inflammation-related genes and signaling pathways.

2022-10-22 | GSE216173 | GEO

Levofloxacin induces the downexpression of inflammation-related transcriptome in the tarsal joint of Spondyloarthritis DBA/1 mice.

Project description:Gene expression profiles in the tarsal joints of DBA/1 mice whit spontaneus arthritis and treated with levofloxacion vs. those who were not received levofloxacin were compared. Levofloxacin induced the downexpression of inflammation-related genes and signaling pathways.

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Treadmill physical exercise on postarthritic phase of collagen induced arthritis in DBA1 mice_transcriptome responses on tarsal joint

Project description:Gene expression profiles in the tarsal joints of DBA/1 mice whit collagen-induced arthritis that performed treadmill exercise in the post-arthritic phase vs. those who were not exercised were compared. Exercise induced the upregulation of inflammatory genes and signaling pathways.

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Treadmill physical exercise on prearthritic phase of collagen induced arthritis in DBA1 mice_transcriptome responses on tarsal joint

Project description:Gene expression profiles in the tarsal joints of DBA/1 mice whit collagen-induced arthritis that performed treadmill exercise in the pre-arthritic phase vs. those who were not exercised were compared. Exercise induced the downregulation of inflammatroy genes and signaling pathways.

2022-08-30 | GSE212262 | GEO

profiling of hypothalamus from arthritic DBA/1 mice vs. control DBA/1 mice

Project description:The main function of the nervous system is to maintain homeostasis by sensing and reacting to signals that reach a certain threshold. For example, the brain can sense immune peripheral events through soluble compounds or the vagus nerve and can react through activation of the hypothalamus-pituitary-adrenal axis, resulting in the modulation of an ongoing immune response. Using microarrays we studied the gene expression profile of the hypothalamus in DBA/1 mice strain that developed collagen induced-arthritis vs control mice. Keywords: gene expression profile of the hypothalamus in response to induction of arthritis

2007-05-02 | GSE7282 | GEO

profiling of midbrain from arthritic DBA/1 mice vs. control DBA/1 mice

Project description:The main function of the nervous system is to maintain homeostasis by sensing and reacting to signals that reach a certain threshold. For example, the brain can sense immune peripheral events through soluble compounds or the vagus nerve and can react through activation of the hypothalamus-pituitary-adrenal axis, resulting in the modulation of an ongoing immune response. Using microarrays we studied the gene expression profile of the midbrain in DBA/1 mice strain that developed collagen induced-arthritis vs control mice. Keywords: gene expression profile of the midbrain in response to induction of arthritis

2007-05-02 | GSE7284 | GEO

Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF driven spondyloarthritis [II]

Project description:Objectives: Gut and joint inflammation commonly co-occur in spondyloarthritis (SpA) which strongly restricts therapeutic modalities. The immunobiology underlying differences between gut and joint immune regulation, however, is poorly understood. We therefore assessed the immunoregulatory role of CD4+FOXP3+ regulatory T (Treg) cells in a model of Crohn’s-like ileitis and concomitant arthritis. Methods: RNA-sequencing (RNA-seq) and flow cytometry were performed on inflamed gut and joint samples and tissue-derived Tregs from TNF∆ARE mice. In situ hybridization of TNF and its receptors (TNFR) was applied to human SpA gut biopsies. Soluble(s) TNFR levels were measured in serum of mice and SpA patients and controls. Treg function was explored by in vitro co-cultures and in vivo by conditional Treg depletion. Results: Chronic TNF exposure induced several TNF superfamily (TNFSF) members (4-1BBL, TWEAK and TRAIL) in synovium and ileum in a site-specific manner. Elevated TNFR2 mRNA levels were noted in TNF∆ARE/+ mice leading to increased sTNFR2 release. Likewise, sTNFR2 levels were higher in SpA patients with gut inflammation and distinct from inflammatory and healthy controls. Tregs accumulated at both gut and joints of TNF∆ARE mice, yet their TNFR2 expression and suppressive function was significantly lower in synovium versus ileum. In line herewith, synovial and intestinal Tregs displayed a distinct transcriptional profile with tissue restricted TNFSF receptor and p38MAPK gene expression. Conclusions: These data point to profound differences in immune-regulation between Crohn’s ileitis and peripheral arthritis. Whereas Tregs control ileitis they fail to dampen joint inflammation. Synovial resident Tregs are particularly maladapted to chronic TNF exposure.

2023-05-22 | GSE232406 | GEO

Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF driven spondyloarthritis [I]

2023-05-22 | GSE232405 | GEO

Transcription profiling of DBA/1J mouse with collagen induced arthritis

Project description:Time course of collagen-induced arthritis in DBA/1J male mice, synchronized on day 28 with 10ug LPS

2009-11-16 | E-TABM-661 | biostudies-arrayexpress

profiling of prefrontal cortex from arthritic DBA/1 mice vs. control DBA/1 mice

Project description:The main function of the nervous system is to maintain homeostasis by sensing and reacting to signals that reach a certain threshold. For example, the brain can sense immune peripheral events through soluble compounds or the vagus nerve and can react through activation of the hypothalamus-pituitary-adrenal axis, resulting in the modulation of an ongoing immune response. Using microarrays we studied the gene expression profile of the prefrontal cortex in DBA/1 mice strain that developed collagen induced-arthritis vs control mice. Keywords: gene expression profile of the prefrontal cortex in response to induction of arthritis

2007-05-02 | GSE7278 | GEO

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