Analysing the effect of cellular energy levels on codon-specific ribosome occupancy in vivo

ABSTRACT: The aim of this study is to evaluate how cellular energy levels shape codon-specific decoding and affect codon-mediated mRNA degradation. To this end we made use of HT5P-seq (Zhang & Pelechano, 2021, PMID:35474692) in S. cerevisiae to footprint the ribosome of co-translationally degraded mRNAs in vivo upon swift changes in the concentration of intracellular ATP and other energy metabolites.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE216524 | GEO | 2024/03/08

REPOSITORIES: GEO