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Transcriptome Profiling of PRRSV Infected Porcine Alveolar Macrophages By Single Cell Sequencing

ABSTRACT: Porcine reproductive and respiratory syndrome (PRRSV) is a devastating pathogen for the pig industry worldwide. PRRSV mainly infects porcine alveolar macrophage (PAM). In the present study, single-cell RNA sequencing (scRNA-seq) was employed to characterize the host transcriptome responses of PAMs infected with a virulent PRRSV strain in vivo and ex vivo. Increase ofpro-inflammatory and anti-apoptotic genes was correlated with the increase of infection (expression of the virus ORF7 transcript).

ORGANISM(S): Sus scrofa

PROVIDER: GSE216865 | GEO | 2023/11/01

REPOSITORIES: GEO

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