Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tracking the progression of Alzheimer’s disease with peripheral blood-based biomarkers

ABSTRACT: We investigate the gene expression signature of peripheral blood monocytes during the progression of Alzheimer's disease. We profiled gene expression in the mouse cortex using data obtained from RNA-seq of three individuals at 6-months old and three individuals at 24-months old.

ORGANISM(S): Homo sapiens

PROVIDER: GSE216918 | GEO | 2022/11/03

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Decoupling of mRNA and protein expression in aging brains reveals the age-dependent adaptation of specific gene subsets

Project description:To investigate the connection between changes of mRNA and protein expression in the brain during aging, we compared the transcriptome and proteome of the mouse cortex. We profiled gene expression in the mouse cortex using data obtained from RNA-seq of three individuals at 6-months old and three individuals at 24-months old.

2023-03-01 | GSE218637 | GEO

Detection of Alzheimer’s Disease at Mild Cognitive Impairment and Disease Progression Using Autoantibodies as Blood-based Biomarkers

Project description:Human serum samples from Alzheimer's disease driven mild cognitive impairment and non-diseased controls were probed onto human protein microarrays in order to identify differentially expressed autoantibody biomarkers that could be used as diagnostic indicators. Other neurodegenerative and non-neurodegenerative diseases were also used to help measure the specificity of the selected biomarkers.

2016-05-03 | GSE74763 | GEO

Project description:Wildtype mice at either 3 or 12 months old were subjected to intrahippocampal injection with sarkosyl insoluble brain extracts from either human control or Alzheimer's disease brain. Mice were incubated for 1, 3 or 5 months and then sacrificed. The hippocampus from one hemisphere was used to extract total RNA that was then subjected to polyA-selection and whole transcriptome sequencing. 3 and 12 month old animals were processed in seperate batches and comparisons between control and Alzheimer's disease injected animals from each timepoint were conducted

2021-08-31 | GSE169686 | GEO

Comprehensive Proteomic Profiling of Urinary Exosomes and Identification of Potential Noninvasive Early Biomarkers of Alzheimer’s Disease in 5XFAD Mouse Model

Project description:To investigate the potential noninvasive early biomarkers of AD in 5XFAD mouse model, we investigate the proteome of urinary exosomes present in 1-month-old (before amyloid-β accumulation) 5XFAD mouse models and their littermate controls. Another two groups of 2 and 6 months-old urinary samples were collected for monitoring the dynamic change of target proteins during AD progression.

2021-01-04 | PXD021935 | Pride

N1-methyladenosine modification in mitochondrial tRNAs is associated with Alzheimer’s disease

Project description:Here we used the newly developed m1A-quant-seq appraoch to map m1A modification transcriptome wide on the cortex of 6 month old BL6 mice and 5XFAD mice (Alzheimer's mouse model).

2022-04-30 | GSE168199 | GEO

Project description:Transcriptome sequencing of five months old and three years old grass carp

| PRJNA634937 | ENA

Alteration of the microRNA network during the progression of Alzheimer’s disease

Project description:We report the high-throughput profiling of microRNAs (miRNAs) from the prefrontal cortex of controls, early and late-stages Alzheimer's disease subjects. We show miRNA expression changes between the two groups and down-regulation of miR-132-3p in the late-stages group.

2013-07-25 | GSE48552 | GEO

Peripheral blood gene expression as a biomarker for early detection of Alzheimer’s disease

Project description:To further development of our gene expression profile of Alzheimer's disease, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential biomarker for early disease detection

2016-08-11 | GSE85426 | GEO

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

Project description:This dataset allows for the exploration of microglial function on gene expression in wild-type and the 5xFAD mouse model of Alzheimer's disease, across multiple brain regions. Mice were treated with the selective CSF1R inhibitor PLX5622, which eliminates >95% of microglia in less than 5 days, from 1.5 to 7 months of age. Thus, these data allow the exploration of the effects, and specificity, of 6 months microglial depletion, in both wild-type and 5xFAD mice.

2019-07-12 | GSE134151 | GEO

A Novel Alzheimer's Disease Drug Candidate Targeting Inflammation and Fatty Acid Metabolism

Project description:CAD-31 has potent neuroprotective properties in six distinct nerve cell assays that mimic toxicities observed in the old brain. Pharmacological and preliminary toxicology studies show that CAD-31 is brain penetrant and likely safe. When fed to old, symptomatic transgenic Alzheimer's disease (AD) mice starting at ten months of age for three additional months in a therapeutic model of the disease, there was a reduction in the memory deficit and brain inflammation, and an increase in the expression of synaptic proteins. Small molecule metabolic data from the brain and plasma showed that the major effect of CAD-31 is centered on fatty acid metabolism and inflammation. Pathway analysis of gene expression data showed that CAD-31 had major effects on synapse formation, AD and energy metabolism.

2017-08-11 | GSE93678 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data