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Epigenome analysis of a pheochromocytoma sample carrying co-ocurrent mutations in NF1 and DLST.

ABSTRACT: Genome wide DNA methylation profiling of a pheochromocytoma sample carrying co-ocurrent mutations in NF1 and DLST. The Illumina Infinium EPIC Human DNA methylation Beadchip v1.2 was used to obtain a DNA methylation profile across approximately 850,000 CpGs. The main goal of this project was to gain insight into the role of these events in tumour development.

ORGANISM(S): Homo sapiens

PROVIDER: GSE217207 | GEO | 2022/11/25

REPOSITORIES: GEO

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Epigenome analysis of a paraganglioma sample carrying the DLST-p.Y422C mutation [methylation array]

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Analysis of pheochromocytoma samples carrying co-occurrent mutations in NF1 and DLST

Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:We performed gene expression profiling analysis using data obtained from RNA-seq of a paraganglioma sample carrying the DLST-p.Y422C mutation. The main goal of this project was to find specific gene expression profiles associated to the presence of mutations in the DLST gene of pheochromocytomas/paragangliomas.

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Epigenome analysis of placenta/cord blood/saliva samples

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