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The evolution of the type I IFN transcriptional response across human populations [PRO-seq]

ABSTRACT: Host-pathogen dynamics have been observed to entail rapid evolution of genes involved in the host innate immune system. Type I interferon cytokines trigger an antiviral cellular state by binding to membrane receptors, encoded in chromosome 21, that transduce a signaling response to induce the transcription of hundreds of interferon-stimulated genes. However, it remains poorly understood how gene transcription regulation has been rewired through evolutionary time, even at relatively short time scales, to achieve inter- and intra-species variation in interferon-controlled changes in gene expression. We generated nascent transcription (PRO-seq) and steady-state mRNA expression (RNA-seq) datasets from human individuals from diverse ethnic backgrounds, and from individuals with trisomy 21, to investigate differences in the transcriptional response triggered by type I interferon within human populations, and to study the interferonopathy related to trisomy 21.

ORGANISM(S): Homo sapiens

PROVIDER: GSE217294 | GEO | 2026/07/27

REPOSITORIES: GEO

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