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Impact of cranial bone-derived mesenchymal stem cell transplantation for functional recovery in experimental spinal cord injury

ABSTRACT: We compared the therapeutic effects and mechanism of transplanted rat cranial bone-derived mesenchmay stem cell (rcMSCs) and rat bone marrow-derived mesenchymal stem cell (rbMSCs) in a rat cervical spinal cord injury (cSCI) model. We performed gene expression profiling analysis using data obtained from RNA-seq of rcMSCs and rbMSCs

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE217362 | GEO | 2025/11/05

REPOSITORIES: GEO

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Impact of cranial bone-derived mesenchymal stem cell transplantation for functional recovery in experimental spinal cord injury

Project description:Impact of cranial bone-derived mesenchymal stem cell transplantation for functional recovery in experimental spinal cord injury

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Project description:The bone tissue undergoes constant turnover, which relies on skeletal stem cells (SSCs) and/or mesenchymal stem cells (MSCs) and their niches. SSCs/MSCs and their perivascular niche within the bone marrow are well characterized in long bones. As for cranial bones, besides bone marrow, the suture mesenchyme has been identified as a unique niche for SSCs/MSCs of craniofacial bones. However, a comprehensive study of the two different cranial stem cell niches at single-cell resolution is still lacking. In addition, during the progression of aging, age-associated changes in cranial stem cell niches and resident cells remain uncovered. In this study, we investigated age-related changes in cranial stem cell niches via single-cell RNA sequencing (scRNA-seq).

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A Novel Method for Isolating Whole Protein from Human Cranial Bone

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