Expression data from Caenorhabditis elegans exposed to albendazole

ABSTRACT: We have investigated how the model nematode Caenorhabditis elegans responds to and metabolizes albendazole; an important anthelmintic for human and animal parasite control. The transcriptional response of the mutant strain CB3474 ben-1(e1880)III, which is highly resistant to benzimidazoles due to a null mutation in the β-tubulin drug target, was examined. This approach was successful in minimizing transcriptional responses associated with non-specific stress or with the drug mode of action, resulting in only in a small subset of genes showing differential expression in response to drug exposure.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE21747 | GEO | 2010/06/14

SECONDARY ACCESSION(S): PRJNA127333

REPOSITORIES: GEO