Dataset Information


Expression data from Caenorhabditis elegans exposed to albendazole

ABSTRACT: We have investigated how the model nematode Caenorhabditis elegans responds to and metabolizes albendazole; an important anthelmintic for human and animal parasite control. The transcriptional response of the mutant strain CB3474 ben-1(e1880)III, which is highly resistant to benzimidazoles due to a null mutation in the β-tubulin drug target, was examined. This approach was successful in minimizing transcriptional responses associated with non-specific stress or with the drug mode of action, resulting in only in a small subset of genes showing differential expression in response to drug exposure. Overall design: Matched cultures of synchronised C. elegans were grown to young adult stage in liquid culture. The nematodes were then exposed to 300 µg/ml albendazole (ABZ) or exposed only to the DMSO excipient used to deliver the albendazole (CONT) for 4 hours. RNA was extracted from three biological replicates and hybridised to Affymetrix arrays.

INSTRUMENT(S): [Celegans] Affymetrix C. elegans Genome Array

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Steven Thomas Laing   

PROVIDER: GSE21747 | GEO | 2010-06-14



altmetric image


Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2014-05-01 | E-GEOD-21747 | ArrayExpress
2011-04-01 | GSE22660 | GEO
2011-04-14 | E-GEOD-22660 | ArrayExpress
| GSE101645 | GEO
| GSE101680 | GEO
2017-07-03 | E-MTAB-5705 | ArrayExpress
| PRJNA395200 | ENA
| GSE16975 | GEO
2007-12-01 | GSE8058 | GEO
2014-06-02 | E-GEOD-16975 | ArrayExpress