Transcriptomics

Dataset Information

22

Expression data from Caenorhabditis elegans exposed to albendazole


ABSTRACT: We have investigated how the model nematode Caenorhabditis elegans responds to and metabolizes albendazole; an important anthelmintic for human and animal parasite control. The transcriptional response of the mutant strain CB3474 ben-1(e1880)III, which is highly resistant to benzimidazoles due to a null mutation in the β-tubulin drug target, was examined. This approach was successful in minimizing transcriptional responses associated with non-specific stress or with the drug mode of action, resulting in only in a small subset of genes showing differential expression in response to drug exposure. Overall design: Matched cultures of synchronised C. elegans were grown to young adult stage in liquid culture. The nematodes were then exposed to 300 µg/ml albendazole (ABZ) or exposed only to the DMSO excipient used to deliver the albendazole (CONT) for 4 hours. RNA was extracted from three biological replicates and hybridised to Affymetrix arrays.

INSTRUMENT(S): [Celegans] Affymetrix C. elegans Genome Array

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Steven Thomas Laing   

PROVIDER: GSE21747 | GEO | 2010-06-14

SECONDARY ACCESSION(S): PRJNA127333

REPOSITORIES: GEO

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