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Sex-determining 3D regulatory hubs revealed by genome spatial auto-correlation analysis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE217618 | GEO | 2022/11/21

REPOSITORIES: GEO

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Sex-determining 3D regulatory hubs revealed by genome spatial auto-correlation analysis [RNA-seq]

Project description:Mammalian sex is determined by a network of antagonistic genes that are well characterized. However, its non-coding regulation is still largely unknown. Here we explore the 3D chromatin landscape of sex determination in vivo. We integrate Hi-C with ChIP-seq experiments using METALoci, a novel genome spatial auto-correlation analysis approach that identifies 3D regulatory hubs across the genome. We uncover a prominent rewiring of chromatin interactions during sex determination. By combining predictive approaches and validations in transgenic mice we identify a novel Fgf9 regulatory hub, which deletion results in male-to-female sex reversal.

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Sex-determining 3D regulatory hubs revealed by genome spatial auto-correlation analysis [Hi-C]

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