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Biallelic TET2 mutation sensitizes to 5’-azacitidine in acute myeloid leukemia. Stolzel et al. JCI Insight. [Illumina Infinium]

ABSTRACT: To investigate the impact of TET2 loss on global genomic methylation in HEL acute myeloid leukaemia (AML) cells. HEL AML cells, which have a monoallelic TET2 mutation, were targeted by CRISPR to inactivate the remaining TET2 allele, generating isogenic cell clones with either monoallelic or biallelic TET2 mutation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE217940 | GEO | 2023/03/08

REPOSITORIES: GEO

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Biallelic TET2 mutation sensitizes to 5’-azacitidine in acute myeloid leukemia. Stolzel et al. JCI Insight. [RNA-Seq]

Project description:To investigate the impact of TET2 loss on global transcription in HEL acute myeloid leukaemia (AML) cells. HEL AML cells, which have a monoallelic TET2 mutation, were targeted by CRISPR to inactivate the remaining TET2 allele, generating isogenic cell clones with either monoallelic or biallelic TET2 mutation.

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Gene expression profiles of mono- and biallelic CEBPA mutations in cytogenetically normal AML

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Gene expression profiles of mono- and biallelic CEBPA mutations in cytogenetically normal AML

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Reply to Soman et al, Alffenaar et al, Metcalfe et al, and Raoult.