Dataset Information


Control of oligodendroglial cell number by the miR-17~92 family of miRNA cluster

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version)

SUBMITTER: Gabriela Salinas-Riester   

PROVIDER: GSE21801 | GEO | 2010-06-01



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Control of oligodendroglial cell number by the miR-17-92 cluster.

Budde Holger H   Schmitt Sebastian S   Fitzner Dirk D   Opitz Lennart L   Salinas-Riester Gabriela G   Simons Mikael M  

Development (Cambridge, England) 20100526 13

The generation of myelinating cells in the central nervous system requires the initiation of specific gene expression programs in oligodendrocytes. We reasoned that microRNAs (miRNAs) could play an important role in this process by regulating crucial developmental genes. Microarray profiling of cultured oligodendrocytes identified the miR-17-92 miRNA cluster as highly enriched in oligodendrocytes. We specifically deleted the miR-17-92 cluster in oligodendrocytes using 2',3'-cyclic nucleotide 3'  ...[more]

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