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RNA sequencing of TCF19 knockdown by siRNA in endometrial cancer cells

ABSTRACT: In our study, TCF19 was found to be upregulated in microsatellite instability (MSI) endometrial cancer and was associated with poor prognosis and immune exhaustion signature. Elevated TCF19 enhanced cell proliferation and migration, which promoted tumorigenicity under non-immunological background; Moreover, tumoral TCF19 expression could also promote CD8+T cell exhaustion in tumor immune microenvironment, which facilitated immune escape and tumor development. Therefore, TCF19 could be a promising biomarker and effective therapeutic target for MSI endometrial cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE218098 | GEO | 2023/08/11

REPOSITORIES: GEO

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Chromatin Immunoprecipitation(ChIP)-seq of TCF19 in endometrial cancer cells

Project description:In our study, TCF19 was found to be upregulated in microsatellite instability (MSI) endometrial cancer and was associated with poor prognosis and immune exhaustion signature. Elevated TCF19 enhanced cell proliferation and migration, which promoted tumorigenicity under non-immunological background; Moreover, tumoral TCF19 expression could also promote CD8+T cell exhaustion in tumor immune microenvironment, which facilitated immune escape and tumor development. Therefore, TCF19 could be a promising biomarker and effective therapeutic target for MSI endometrial cancer.

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Colorectal cancers with microsatellite instability display unique miRNA profiles

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Characterization of a novel hormone-responsive endometrial cancer cell line: HCI-EC-23 [RNA-seq]

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