Transcriptomics

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Isogenic pairs of MPS VI gene corrected iPSC and Chondrogenic cells


ABSTRACT: To investigate the effect of MPS VI on gene expression in chondrogenic cells, we gene corrected four patient derived hiPSC using a ARSB knock-in into the AAVS1 locus. We differentiated cells into chondrogenic cells using a 14 day protocol, we proformed gene expression profiling analysis using data obtained from RNA-seq at iPS stage in monoplo and differentiated cells in triplo.

ORGANISM(S): Homo sapiens

PROVIDER: GSE218101 | GEO | 2022/12/28

REPOSITORIES: GEO

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