Transcriptomic alteration of bone-related cells in aged mice after long-term high fat diet (HFD) feeding

ABSTRACT: Aging is associated with osteoporosis and remodeling of bone marrow microenvironment, skewing hematopoiesis. Obesity may accelerate aging process. We use bulk-RNA sequencing to measure the transcriptomic changes of bone cells caused by long-term HFD feeding in aged mice, which mainly includes osteocytes and other bone marrow stromal cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE218105 | GEO | 2023/11/15

REPOSITORIES: GEO