Transcriptomics

Dataset Information

25

Genome-wide analysis of impact of B cells from the peripheral blood of chronic lymphocytic leukemia (CLL) patients versus B cells from healthy donors on CD14+ PBMCs from healthy donors


ABSTRACT: CD14+ cells in the PBMCs of CLL patients are converted into NLCs. CD14+ PBMCs from healthy donors when cultured with CLL cells give rise to differentiated cells called CD14CLL-cells, which are immunophenotypically similar to NLCs. CD14+ PBMCs from healthy donors when cultured with non-malignant B cells give rise to differentiated cells called CD14B-cells. Transcriptome wide analysis reveals genes involved in immune response to be significantly deregulated between CD14B-cells and CD14CLL-cells/NLCs. Overall design: Total RNA obtained from NLCs, CD14CLL-cells and CD14B-cells and hybridised to arrays (4 samples in each group)

INSTRUMENT(S): Illumina HumanHT-12 V3.0 expression beadchip

ORGANISM(S): Homo sapiens  

SUBMITTER: Nupur Bhattacharya  

PROVIDER: GSE21838 | GEO |

SECONDARY ACCESSION(S): PRJNA126923

REPOSITORIES: GEO

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