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Comparing transcriptional effects of radioprotection with dmPGE2 to that of other EP receptor agonists in both hematopoietic stem cells and bone marrow stromal cells

ABSTRACT: We report transcriptional analyses of individual and combined EP receptor stimulation in radioprotective administration of dmPGE2 and other EP receptor agonists with varying radioprotective capacities. We find that in both hematopoietic stem cells, and in BM stromal (non-hematopoietic) cells, dmPGE2 radioprotection is primarily mediated through EP4 stimulation, but full activity likely requires interactive stimulation of both EP4 and EP3.

ORGANISM(S): Mus musculus

PROVIDER: GSE218443 | GEO | 2023/05/19

REPOSITORIES: GEO

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