Dataset Information


Gene Expression Profiling of C. elegans - ets-4 Mutant Animals Vs Wild-type

ABSTRACT: The gene expression profile of WT (N2) C. elegans were compared to that of ets-4(ok165) and ets-4(uz1) mutant animals Overall design: Total RNA was extracted from L4 larval stage WT, ets-4(ok165) and ets-4(uz1) worms and used to detect the differences in gene expression profiles of ets-4 mutant animals from WT

INSTRUMENT(S): Agilent-012795 C. elegans Oligo Microarray G2518A Option 002 (Probe Name version)

SUBMITTER: Bargavi Thyagarajan  

PROVIDER: GSE21851 | GEO | 2010-05-15



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ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans.

Thyagarajan Bargavi B   Blaszczak Adam G AG   Chandler Katherine J KJ   Watts Jennifer L JL   Johnson W Evan WE   Graves Barbara J BJ  

PLoS genetics 20100916 9

Aging is a complex phenotype responsive to a plethora of environmental inputs; yet only a limited number of transcriptional regulators are known to influence life span. How the downstream expression programs mediated by these factors (or others) are coordinated into common or distinct set of aging effectors is an addressable question in model organisms, such as C. elegans. Here, we establish the transcription factor ETS-4, an ortholog of vertebrate SPDEF, as a longevity determinant. Adult worms  ...[more]

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