Massively parallel engineering of persistent CAR-Ts [GEO_CLASH_Integration_off_targets]

ABSTRACT: To identify immune-related gene perturbations that enhance CAR-T cell persistence in in vitro and in vivo settings, we generated thousands of CAR-T variants using the CLASH platform and evaluated crRNA representation across time in in vitro and in vivo cancer models.

ORGANISM(S): Homo sapiens

PROVIDER: GSE218659 | GEO | 2022/12/09

REPOSITORIES: GEO