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Transcriptomic changes driving pulmonary fibrosis resolution in young and old Bleomycin-treated mice

ABSTRACT: Bleomycin-induced pulmonary fibrosis in mice mimics major hallmarks of idiopathic pulmonary fibrosis, yet in this model it spontaneously resolves over time. We studied molecular mechanisms of fibrosis resolution and lung repair, focusing on transcriptional and proteomic signatures and the effect of aging. Old mice showed delayed and incomplete lung function recovery 8 weeks after Bleomycin instillation. This shift in structural and functional repair in old Bleomycin-treated mice was reflected in a temporal shift in gene and protein expression. We reveal gene signatures and signaling pathways which underpin the lung repair process.

ORGANISM(S): Mus musculus

PROVIDER: GSE218997 | GEO | 2023/10/16

REPOSITORIES: GEO

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