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Gene expression in Lineage negative bone marrow cells of C57B/L6 and B.D(Chr5) mice

ABSTRACT: These mouse strains differ in absolute numbers of hematopoietic stem cells but differ genetically only at the Chr 5 congenic locus. We used microarray analysis to identify candidate regulators of hematopoietic stem cells based on differential gene expression patterns.

ORGANISM(S): Mus musculus

PROVIDER: GSE21905 | GEO | 2010/05/21

SECONDARY ACCESSION(S): PRJNA126825

REPOSITORIES: GEO

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Gene expression in Lineage negative bone marrow cells of C57B/L6 and B.D(Chr5) mice

Project description:These mouse strains differ in absolute numbers of hematopoietic stem cells but differ genetically only at the Chr 5 congenic locus. We used microarray analysis to identify candidate regulators of hematopoietic stem cells based on differential gene expression patterns. Triplicate RNA samples were isolated from 500,00-800,000 Lineage negative bone marrow cells from each strain. Each of the six samples were analyzed on 6 separate MG 430 2.0 Affymetrix Microarray Chips.

2010-06-08 | E-GEOD-21905 | biostudies-arrayexpress

Gene expression in LSK cells of C57B/L6, DBA/2J, B.D(Chr5), & D.B(Chr5) mice

2010-05-21 | GSE21896 | GEO

Gene expression in LSK cells of C57B/L6, DBA/2J, B.D(Chr5), & D.B(Chr5) mice

Project description:These mouse strains differ in absolute numbers of hematopoietic stem cells but differ genetically only at the Chr 5 congenic locus. We used microarray analysis to identify candidate regulators of hematopoietic stem cells based on differential gene expression patterns. Triplicate RNA samples, except for duplicate DBA/2J samples, were isolated from 80,00-137,000 LSK cells from each strain. Each of the 11 samples were analyzed on individual microarrays on two Illumina Sentrix-Mouse 6 Whole Genome Expression Beadhips.

2010-05-21 | E-GEOD-21896 | biostudies-arrayexpress

Transcription profiling of mouse stromal cell compartment, lineage negative, CD45 negative bone marrow cells from C57B/L6 and B6.SJL (Ly5.1) strains

Project description:Comparison of gene expression in the stromal cell compartment (Lineage negative, CD45 negative bone marrow cells) of C57B/L6 and B6.SJL (Ly5.1) mice. duplicate samples were analyzed per strain (two biological replicates) and each of the two samples was pooled from 5 mice

2010-01-20 | E-TABM-829 | biostudies-arrayexpress

Kidneys of Dahl salt sensitive rats

Project description:Gene expression profiling of kidney tissue from 5 week old Dahl salt sensitive rats and congenic strain of Chr.10 Dahl salt sensitive rats. Keywords: other

2003-08-20 | GSE413 | GEO

Absolute quantification of CD34(+)/CD133(-) hematopoietic stem cells

Project description:Absolute quantification of CD34(+)/CD133(-) hematopoietic stem cells

| PRJNA116757 | ENA

Gene expression profiling in a congenic strain identifies candidate genes for nutrient intake QTL on mouse chromosome 17

Project description:The goal of this experiment was to identify genes contributing to fat, carbohydrate, and total calorie intake in mice by comparing gene expression in liver and hypothalamus of an interval-specific congenic strain, B6.CAST-17, with that of the control strain. This congenic strain has previously confirmed genetic loci on Chr 17 linked to increased carbohydrate (Mnic1) and kilocalorie (Kcal2) intake. Keywords: Comparative gene expression analysis

2007-12-11 | GSE6507 | GEO

Transcription profiling of kidney tissue from 5 week old Dahl salt sensitive rats and congenic strain of Chr.10 Dahl salt sensitive rats

Project description:Gene expression profiling of kidney tissue from 5 week old Dahl salt sensitive rats and congenic strain of Chr.10 Dahl salt sensitive rats.

2008-04-03 | E-GEOD-413 | biostudies-arrayexpress

Genetic variation in Glp1r expression influences the rate of gastric emptying

Project description:A C57BL6/J (B6) x CAST/Ei (CAST) strain intercross has revealed a new quantitative trait locus (QTL) on Chromosome (Chr) 17 controlling total food volume (Tfv1; LOD=7.6). Compared with B6, the CAST mice consume 39% more food volume per body weight in a macronutrient diet selection paradigm. Linkage analyses of total food volume revealed the presence of suggestive QTL on Chrs 2, 6, and 15 and a significant locus on Chr 17. An interval-specific congenic strain, B6.CAST-17, was then developed which verified the QTL. Microarray analysis of stomach in congenic and wildtype B6 mice revealed Glp1r as an expression candidate with physiological relevance to food intake. Further functional analysis of this gene revealed this gene as potential candidate for total food volume trait in mice Keywords: Comparative gene expression analysis

2008-02-13 | GSE7756 | GEO

Gene expression regulating the onset of heat-induced intratesticular calcification.

Project description:We compared gene expression profiles between testes from C57BL/6 and C57BL/6-background congenic mouse strain B6.MRLc1-(D1Mit202–D1Mit403) carrying the telomeric region of MRL-type Chr 1 (67.97–81.63 cM) at 10 days after a single scrotal heat stress of 43°C for 20 min.

2014-08-01 | GSE53139 | GEO

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