Effect of SASP factors on mouse intestinal organoids [bulk RNA-seq]

ABSTRACT: We report bulk RNAseq data from the mouse intestinal organoids cultured in different conditions. Differential gene expression analysis revealed a large overlap in induced genes between Wnt5a and SCM, consistent with a major contribution of non-canonical Wnt signaling to the SCM-induced cystic organoid phenotype. Of genes differentially regulated by Wnt5a and SCM, about half were Ptk7 dependent, which displayed strong enrichment for TEAD binding motifs.

ORGANISM(S): Mus musculus

PROVIDER: GSE219126 | GEO | 2022/12/06

REPOSITORIES: GEO