CRISPR screens identify gene targets at breast cancer risk loci [ATAC-seq]

ABSTRACT: Genome-wide association studies (GWAS) have identified >200 loci associated with breast cancer (BC) risk. The majority of candidate causal variants (CCVs) are in non-coding regions and likely modulate cancer risk by regulating gene expression. However, pinpointing the exact target of the association, and identifying the phenotype it mediates, is a major challenge in the interpretation and translation of GWAS.

ORGANISM(S): Homo sapiens

PROVIDER: GSE219163 | GEO | 2023/03/09

REPOSITORIES: GEO