Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ChIP-seq analysis in Cal-62 cells treated with Niraparib

ABSTRACT: To assess the function of Niraparib in thyroid cancer, we performed transcriptome analysis through high-throughput CHIP-Seq of PARP1 in DMSO and Niraparib treated Cal-62 cells Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for PARP1 in DMSO and Niraparib treated Cal-62 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE219292 | GEO | 2025/11/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA-seq analysis in Cal-62 cells treated with Niraparib

Project description:To assess the function of Niraparib in thyroid cancer, we performed transcriptome analysis through high-throughput RNA-Seq of DMSO and Niraparib treated Cal-62 cells

2025-11-01 | GSE217620 | GEO

ChIP-seq analysis in Cal-62 cells treated with Niraparib

Project description:ChIP-seq analysis in Cal-62 cells treated with Niraparib

| PRJNA907860 | ENA

RNA-seq analysis in Cal-62 cells treated with Niraparib

Project description:RNA-seq analysis in Cal-62 cells treated with Niraparib

| PRJNA899836 | ENA

RNA-seq of CAL-62 cells transfected with LINC00886 smart silencer and negative control

Project description:We extracted total RNA samples for high-through RNA sequencing from CAL-62 cells transfected with LINC00886 smart silencer and negative control. Then RNA-seq analyses were generated by deep sequencing using Illumina Hiseq.

2022-10-09 | GSE214782 | GEO

Hsa-miR-139-5p expression regulates the abundance of proteins related to poor survival cancer in CAL-62 thyroid cancer cell line

Project description:We studied the impact of hsa-miR-139-5p on the protein output by means of an iTRAQ-based approach. First, we established two CAL-62 isogenic cell lines expressing either the mature hsa-miR-139-5p or a non-targeting control upon a doxycycline inducible promoter (PTRE3G-tGFP, Dharmacon). Total proteins of P-tGFP-hsa-miR139-5p untreated or treated with doxycycline (1ug/ml) for 96 and 120 hours were isolated and labeled with iTRAQ® reagent 8-plex. Two independent experiments were performed.

2019-08-13 | PXD011901 | Pride

Niraparib treatment of metastatic melanoma in vivo

Project description:Twenty four NSG mice (3 groups, 8 mice/group) were injected subcutaneoulsy with melanoma PDX cells (MM425X). When tumors reached 100mm3, daily i.p. injections of 25mg/kg niraparib were administred to the tumor bearing mice for 30 days. The treatment resulted in significant anti-tumor effects against MM425X. To determine the transcriptomic profiles altered following niraparib treatment, RNA-Seq was performed in MM-425 tumors from three mice treated with niraparib compared with three mice treated with vehicle. To that end, 3 tumors/group (vehicle vs Niraparib treated) were harvested for RNA extraction. RNA extraction from flash-frozen tissue samples was performed as previously described (Olsson et al., 2016, Salomonis et al., 2010, Soroceanu et al., 2013). Total RNA was extracted from PDX tumor tissues using the RNeasy tissue kit (Qiagen) after tissue disruption using ruptor disposable probes and the concentration measured by Qubit RNA HS Assay Kit (ThermoFisher Scientific). RNA-Seq was performed from ~500ng of total RNA processed using TruSeq polyA selection, at a target depth of 40 million paired-end, stranded reads on an Illumina 2500

2021-07-31 | GSE163424 | GEO

Determine PARP1 and PARP2 target engagment of Niraparib and Olaparib in live cells

Project description:Determine the target engagment of PARP inhibitors (Niraparib and Olaparib) to PARP1 and PAPR2 in live cells using isothermal dose-response experiments

2025-05-13 | PXD044332 | Pride

RNA-seq of CAL-62 cells transfected with LINC00886 smart silencer and negative control

Project description:RNA-seq of CAL-62 cells transfected with LINC00886 smart silencer and negative control

| PRJNA887064 | ENA

Streptomyces sp. 62 strain:62

Project description:Streptomyces sp. 62 strain:62 Genome sequencing

| PRJNA402574 | ENA

RNAseq data for HGSOC PH039 PDXs at baseline and treated with cycles of 100 mg/kg niraparib for 21 days for four treatment rounds

Project description:RNAseq data for HGSOC PH039 PDXs at baseline and treated with cycles of 100 mg/kg niraparib for 21 days for four treatment rounds.

2021-06-16 | GSE163854 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data