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19

Genome-wide binding pattern of PU.1 in normal erythroid progenitors and erythroleukemia cells


ABSTRACT: We find that the myeloid master regulatory transcription factor, PU.1, binds to >16,000 sites in both normal and leukemic erythroid cells. Of these bound sites, ~7,000 lie within 2kb of TSS of a gene, suggesting PU.1 may regulate a large number of genes in erythroid cells. Coupling this data with gene expression analysis, we show PU.1 directly regulates several critical signaling pathways in erythroid cells. Overall design: Assaying PU.1 occupancy in normal and leukemic erythroid cells

INSTRUMENT(S): Illumina Genome Analyzer II (Mus musculus)

ORGANISM(S): Mus musculus  

SUBMITTER: Sandeep Nagaraj Wontakal  

PROVIDER: GSE21950 | GEO |

SECONDARY ACCESSION(S): PRJNA129391

REPOSITORIES: GEO

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