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Single cell transcriptome profiling of kidney cell populations and the effect of liraglutide in diabetes

ABSTRACT: While incretin-based therapies are known to improve glucose control in diabetes, growing evidence suggests a glucose-independent mechanism in protection against kidney disease. To further investigate incretin effects in kidney, we examined long-term therapy with liraglutide, a Glucagon-like peptide 1 receptor (GLP1R) agonist, in diabetic (Ins2Akita) and control mice and profiled renal cell transcriptomes using single-cell sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE220045 | GEO | 2024/05/02

REPOSITORIES: GEO

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