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Ponatinib-induced cardiotoxicity is driven by S100A8/A9-NLRP3-IL-1β signaling mediated excessive inflammation

ABSTRACT: To delineate the underlying molecular mechanisms of ponatinib-induced cardiotoxicity, we used we a comorbitity cardiotoxicity mouse model (high fat-fed ApoE-/- mice) treated for two weeks with placebo/ or Ponatinib We then performed gene expression profiling analysis on left ventricular tissues from the two mouse groups

ORGANISM(S): Mus musculus

PROVIDER: GSE220121 | GEO | 2023/02/08

REPOSITORIES: GEO

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