Genomics

Dataset Information

0

HO-1 modulates the expression of genes involved in inflammation, angiogenesis, proliferation, apoptosis and cell adhesion in human lung cancer cells.


ABSTRACT: The enzymatic activity of HO-1 results in decreased oxidative stress, attenuated inflammatory response, and very often in a lower rate of apoptosis. This is due to removal of heme, a potent prooxidant and proinflammatory agent, but mainly because of generation of biologically active products such as CO and bilirubin. In order to find the correlation between the HO-1 level and the expression of different genes of interest we have utilized human lung cancer cell line NCI-H292 stably overexpressing HO-1. Additionally we have checked if HO-1 can modulate genes expression in NCI-H292 cells treated with TNF. The effect of HO-1 overexpression on transcriptome was assessed by microarray analysis. We have observed that the increase in HO-1 level may affect the expression of different genes involved in cytokine synthesis, angiogenesis, apoptosis, proliferation and cell adhesion. Additionally, HO-1 may interact with the TNF treatment and influence the expression of some genes like IL-1, IL-6, IL-8, FAS and NF-kB.

ORGANISM(S): Homo sapiens

PROVIDER: GSE22030 | GEO | 2011/10/19

SECONDARY ACCESSION(S): PRJNA127459

REPOSITORIES: GEO

Similar Datasets

| E-GEOD-22030 | biostudies-arrayexpress
| E-GEOD-37779 | biostudies-arrayexpress
2013-04-27 | GSE37779 | GEO
2011-02-15 | GSE20404 | GEO
| E-GEOD-20404 | biostudies-arrayexpress
2024-02-14 | GSE236536 | GEO
2024-03-24 | GSE228216 | GEO
| PRJNA41741 | ENA
2024-02-14 | GSE237563 | GEO
| E-GEOD-22323 | biostudies-arrayexpress