Stereopure phosphoryl guanidine backbone chemistry increases the potency and durability of gene silencing by RNA interference

ABSTRACT: To investigate the potential of "off target" of RNAi knockdown, primary mouse hepatocytes were treated with molecules targeting Ttr. We then performed gene expression profiling analysis using data obtained from RNA-seq of cell at two different doses along with an untreated control.

ORGANISM(S): Mus musculus

PROVIDER: GSE220502 | GEO | 2023/05/25

REPOSITORIES: GEO