Intrinsic innate immunostimulation by small circRNA vaccines [tumor]

ABSTRACT: Various RNAs have been shown to elicit innate immunity by activating endosomal PRRs such as Toll-like receptors 3/7/8 (TLR3/7/8), and cytosolic PRRs (e.g., retinoic acid-inducible gene I (RIG-I), melanoma differentiation-associated protein 5 (MDA5)). Such innate immunity provides cytokines and co-stimulation signals that are essential for adaptive immunomodulation.

ORGANISM(S): Mus musculus

PROVIDER: GSE221085 | GEO | 2023/12/31

REPOSITORIES: GEO