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Sirtuin 6 is a negative regulator of FcεRI signaling and anaphylactic responses

ABSTRACT: Sirt6 acts as a negative regulator of FcεRI signaling cascade in mast cells by suppressing PTPRC transcription. Activation of Sirt6 may therefore represent a promising and novel therapeutic strategy for anaphylaxis.

ORGANISM(S): Mus musculus

PROVIDER: GSE221092 | GEO | 2022/12/20

REPOSITORIES: GEO

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