Project description:We profiled a subset of medullary thymic epithelial cells from three mouse strains by scRNA-seq to investigate the composition of the mimetic cell compartment.
Project description:We profiled medullary thymic epithelial cell subsets from a variety of conditions by scRNA-seq to investigate mechanisms of T-cell tolerance.
Project description:Thymic epithelial tumors (TETs) belong to a group of tumors that rarely occur, but have unresolved mechanisms and heterogeneous clinical behaviors. Current care of TET patients demands biomarkers of high sensitivity and specificity for accurate histological classification and prognosis management. In this study, 90 fresh-frozen tissue samples were recruited to generate a quantitative and systematic view of proteomic landscape of TETs by data independent acquisition mass spectrometry (DIA-MS) leading to discovery of novel classifying molecules among different TET subtypes.
Project description:To characterize thymic APCs in an unbiased manner, we generated a scRNA-seq atlas of thymic antigen presenting cells (APCs) isolated from thymic rosettes, cellular complexes of physically interacting thymocytes and APCs. Around 8,000 APCs were captured, mostly haematopoietic in origin, consisting of B cell, dendritic cell and macrophage lineages.
Project description:iNKT cells show significant lineage diversity among mouse strains. We used scRNA-seq to analyze the diversity of thymic iNKT cells between BALB/c and B6 mice.
