Mycobacterium avium subsp. paratuberculosis antigens induce cellular immune responses in cattle

ABSTRACT: Mycobacterium avium subspecies paratuberculosis (MAP) causes chronic progressive granulomatous enteritis leading to diarrhea, weight loss, and eventual death in ruminants. Commercially available vaccines provide only partial protection against MAP infection and can interfere with the use of current diagnostic tests for bovine tuberculosis in cattle. In the current study, we characterized immune responses in calves to vaccines containing either MAP fusion protein particles (MAP antigens Ag85A202-347-SOD1-72 -Ag85B173-330-74F1-148+669-786 as a fusion), recombinant MAP (rMAP) fusion protein or commercially available Silirum(R) vaccine.

ORGANISM(S): other sequences Bos taurus

PROVIDER: GSE221544 | GEO | 2022/12/21

REPOSITORIES: GEO