Transcriptomics

Dataset Information

27

Entrapment Neuropathy Results in Different MicroRNAs Expression Patterns from Denervation Injury in Rats


ABSTRACT: To compare the microRNAs (miRNAs) expression profile in the innervated soleus muscle and L4-L6 DRG neuronsafter sciatic nerve entrapment with a non-constrictive silastic tube, subsequent surgical decompression, and denervation injury. The experimental soleus muscles and dorsal root ganglions (DRGs) from each experimental group (sham control, denervation, entrapment, and decompression) were analyzed with an Agilent® rat miRNA array to detect dysregulated miRNAs Overall design: Three-condition experiment, DRGs and soleus muscles of the rats receiving sciatic nerve denervation 6 months, sciatic nerve entrapment 6 months, and sciatic nerve entrapment 6 months then decompression for 3 months v.s. soleus muscle (sham control), Biological replicates: 1 control replicates, 3 experiment replicates

INSTRUMENT(S): Agilent custom rat miRNA array v2

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Ching-Hua Hsieh  

PROVIDER: GSE22181 | GEO | 2010-06-12

SECONDARY ACCESSION(S): PRJNA128813

REPOSITORIES: GEO

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