BDNF-TrkB signalling depletion from the indirect pathway spiny projection neurons (iSPN) leads to age-dependent spontaneous hyperlocomotion.

ABSTRACT: Therefore, we have established a unique mouse model that provides a rare example of an age-dependent locomotor defect to identify the genes and associated molecular pathways relevant to maintaining locomotor control. Thus, we performed gene expression profiling analysis using data from RNA-seq of 2 different striatal populations at two time points in the presence and absence of the TrkB signalling.

ORGANISM(S): Mus musculus

PROVIDER: GSE221922 | GEO | 2024/09/05

REPOSITORIES: GEO