Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide Human Placenta Enhancer Identification and Association with Function, Differentiation, and Disease [RNA-seq]

ABSTRACT: Placental gene expression changes associated with advancing gestational age in weeks or by trimester were identified by differential expression analysis

ORGANISM(S): Homo sapiens

PROVIDER: GSE222032 | GEO | 2023/09/22

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Genome-wide Human Placenta Enhancer Identification and Association with Function, Differentiation, and Disease.

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-09-22 | GSE222035 | GEO

Effects of maternal choline intake on placental gene expression

Project description:To explore the influence of maternal choline intake on placental gene expression, we employed whole genome microarray expression profiling to identify genes that were differentially expressed in placental tissues obtained from women consuming two different doses (480 vs. 930 mg/d) of choline throughout the third trimester of pregnancy. Healthy third trimester (gestational week 26-29) pregnant women were randomized to a 12-week choline controlled feeding study. The participants consumed either 480 (n=6) or 930 (n=6) mg choline/d. Full thickness placental samples were collected at delivery to extract RNA and perform the arrays. Healthy third trimester (gestational week 26-29) pregnant women were randomized to a 12-week choline controlled feeding study. The participants consumed either 480 (n=6) or 930 (n=6) mg choline/d for 12 weeks. Placental samples were obtained at delivery

2012-07-12 | E-GEOD-39290 | biostudies-arrayexpress

Genome-wide Human Placenta Enhancer Identification and Association with Function, Differentiation, and Disease [PRO-seq]

Project description:Genome-wide sites of active transciption were determined using an in-vitro transcription assay and filtered to identify extragenic enhancer RNAs (eRNAs) as markers of active genomic regulatory regions

2023-09-22 | GSE222031 | GEO

Genome-wide Human Placenta Enhancer Identification and Association with Function, Differentiation, and Disease [CHIP-seq]

Project description:Histone modifications associated with genomic enhancer regions (H3K27ac, H3K4me1) were assayed to identify dynamic changes in genomic regulatory regions in human placenta tissue across gestation

2023-09-22 | GSE222030 | GEO

Proteome analysis of the murine primary placenta

Project description:The placenta regulates maternal-fetal communication, and its defect leads to significant pregnancy complications. The maternal and embryonic circulations are primitively connected in early placentation, but the function of the placenta during this developmentally essential period is relatively unknown. We thus performed a comparative proteomic analysis of the placenta before and after primary placentation and found that the metabolism and transport of lipids were characteristically activated in this period. The placental fatty acid (FA) carriers in specific placental compartments were upregulated according to gestational age, and metabolomic analysis also showed that the placental transport of FAs increased in a time-dependent manner. Further analysis of two mutant mice models with embryonic lethality revealed that lipid-related signatures could reflect the functional state of the placenta. Our findings highlight the importance of the nutrient transport function of the primary placenta in the early gestational period and the role of lipids in embryonic development.

2023-09-06 | PXD026858 | Pride

Epigenome analysis of placenta samples

Project description:Genome wide DNA methylation profiling of placental samples from the Extremely Low Gestational Age Newborn (ELGAN) study

2017-10-25 | GSE106089 | GEO

Placental microRNA sequencing data from human placenta

Project description:miRSeq dataset includes 52 human placentas representing samples from three trimesters. 5 first trimester, 7 second trimester and 40 term samples. Term samples consist of 5 groups (n=8 samples in the group) of normal pregnancy, and cases of late-onset preeclampsia (LO-PE), gestational diabetes (GD), small-and large-for-gestational-age newborns (SGA, LGA) at term.

| EGAS00001005378 | EGA

RNA-seq of human first and second trimester placenta

Project description:The study compares expression differences between first and second trimester placenta in humans. RNA-Sequencing was performed on villi obtained at 7-8 (n=8) and 13-14 (n=6) weeks’ gestational age.

2021-06-02 | E-MTAB-9203 | biostudies-arrayexpress

Differential expression of microRNAs in porcine placenta on gestational days 26 and 50

Project description:Affymetrix miRNA arrays were used to generate miRNA profiles in placenta of Meishan and Yorkshire pigs on stages of initiation (gestational day 26) and establishment (gestational day 50) of placental folds development. The study allowed for the determination of the miRNAs that were differentially expressed in porcine placenta on different gestational day. This study will provide the information to better understanding of the role miRNAs in porcine placental development.

2015-10-01 | GSE62996 | GEO

Effects of maternal choline intake on placental gene expression

2012-07-13 | GSE39290 | GEO