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Transcriptome profiling of mRNAs in cortex of rats with cerebral ischemia and reperfusion treated by acupuncture

ABSTRACT: We analyzed transcriptomic characteristic of motor cortex from Sprague-Dawley rats brain with cerebral ischemia and reperfusion (CIR) treated by acupuncture.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE222705 | GEO | 2024/01/12

REPOSITORIES: GEO

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Transcriptome profiling of mRNAs in cortex of rats with cerebral ischemia and reperfusion

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Transcriptome profiling of mRNAs in cortex of rats with cerebral ischemia and reperfusion treated by acupuncture

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Transcriptomic and metabolomic Profiling reveal the protective effect of Acanthopanax senticosus (Rupr. & Maxim.) Harms combined with Gastrodia elata Blume on cerebral ischemia-reperfusion injury

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Project description:Transcriptomics has played valuable roles in deciphering differences between normal and diseased conditions at the molecular level. Herein is presented a transcriptome profile of ischemia-reperfusion (I/R) injury in adult Sprague-Dawley rat model and control group. Following acute I/R induction, a pool of the rats’ retinas at 12hr post I/R was made. RNA sequencing was performed on both the model and the control groups, followed by their transcriptomic analyses. Sample validation and quality control were done in accordance with standard protocols. Comparison of the sequenced data revealed significant variations in genes expression between the I/R model and their sham counterparts. These differentially expressed genes may provide valuable information to understanding the molecular mechanisms underlying retinal cell dysfunction, cell death and structure collapse in adult rats, and may help characterize or develop therapeutic interventions for visual impairment.

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