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Effect of TIF1γ gene deletion on hematopoietic stem cells

ABSTRACT: Analysis of KLS cells purified from bone marrow of mice conditionally inactivated for TIF1γ gene. TIF1γ deletion results in multiple defects in adult hematopoiesis. Results provide insight into the role of TIF1γ in hematopoietic stem cells functions. We used microarrays to characterize the molecular mechanisms underlying the biological properties of KLS cells lacking TIF1γ

ORGANISM(S): Mus musculus

PROVIDER: GSE22280 | GEO | 2012/06/25

SECONDARY ACCESSION(S): PRJNA128709

REPOSITORIES: GEO

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Effect of TIF1γ gene deletion on hematopoietic stem cells

Project description:Analysis of KLS cells purified from bone marrow of mice conditionally inactivated for TIF1γ gene. TIF1γ deletion results in multiple defects in adult hematopoiesis. Results provide insight into the role of TIF1γ in hematopoietic stem cells functions. We used microarrays to characterize the molecular mechanisms underlying the biological properties of KLS cells lacking TIF1γ KLS (lin-,c-kit+, Sca+) cells were purified by cell sorting

2012-06-24 | E-GEOD-22280 | biostudies-arrayexpress

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HSC expression array

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Gene-expression changes resulting from loss of the mTORC1 component Raptor in murine hematopoietic stem and progenitor cell-enriched populations (HSPC)

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