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Single-cell analysis of tobacco-associated lung adenocarcinoma development

ABSTRACT: Understanding cellular processes underlying early lung adenocarcinoma (LUAD) development is needed to devise intervention strategies. Here, we performed single-cell RNA sequencing (scRNA-seq) of mouse lungs from Gprc5a-/- mice during lung tumor development. We coupled scRNA-seq analysis with spatial transcriptomics of tumor-bearing lungs.

ORGANISM(S): Mus musculus

PROVIDER: GSE222901 | GEO | 2024/02/16

REPOSITORIES: GEO

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Single-cell and spatial transcriptomics analysis of tobacco-associated lung adenocarcinoma development, and in response to targeting inflammation alone or in combination with immune checkpoint blockade in precancerous phase [Spatial transcriptomics]

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