Effect of androgen induction and AR depletion on gene expression of metastatic prostate cancer-specific long noncoding RNAs in prostate cancer cells.

ABSTRACT: We identified 27 long noncoding RNAs with differential expression (DE-lncRNAs) between prostate cancer metastases and corresponding primary tumors, suggesting that they are metastatic castration resistant prostate cancer (mCRPC)-specific lncRNAs. To assess androgen regulation of the DE-lncRNAs, we investigated their expression in LNCaP and VCaP cells induced with dihydrotestosterone (DHT) as well as in androgen receptor (AR)-silenced cells by using RNA-sequencing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE223024 | GEO | 2023/05/04

REPOSITORIES: GEO