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Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy

ABSTRACT: Introduction: Post-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients with TBI. Methods: Clinical samples from patients with more brain severity demonstrated altered mRNAs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE223245 | GEO | 2023/02/02

REPOSITORIES: GEO

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