Impact of MEM40 and IFNB on human DC activation markers

ABSTRACT: To determine the impact of MEM40 and IFNB on normal human donor monocyte-derived DCs (Mo-DCs) phenotype, we used an experimental design where human A549 lung cancer cells were first infected with Ad-Null or adenoviruses expressing human IFNB, MEM40 or MEM40 + IFNB, followed by removal of virus-containing supernatant and co-culture with Mo-DCs. We used the above design followed by sorting of MHC-II+ CD11c+ cells for bulk RNA-sequencing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE223342 | GEO | 2023/02/13

REPOSITORIES: GEO