PD-L1 regulates dendritic cell ferroptosis during immunogenic chemotherapy [scRNA-seq]

ABSTRACT: Dendritic cells (DCs) express high levels of PD-L1 in the tumor microenvironment and draining lymph nodes. Here, we explore the roles of PD-L1 signaling during immunogenic chemotherapy. DC-conditional PD-L1 knockout mice were inoculated with MC38-OVA tumors and treated with doxorubicin. T cells were isolated from draining lymph node for single cell RNA sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE223509 | GEO | 2024/09/23

REPOSITORIES: GEO