MiRNA profiles of EVs released from menstrual blood-derived stem cells
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ABSTRACT:
ORGANISM(S): Homo sapiens
PROVIDER: GSE223537 | GEO | 2023/01/24
REPOSITORIES: GEO
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2013-06-19 | E-GEOD-47897 | biostudies-arrayexpress
Project description:Extracellular vesicles (EVs) play a crucial role in facilitating intercellular communication. The microRNA profiles carried by EVs often exhibit variations between tumor patients and healthy individuals, making them promising biomarkers. These biomarkers are implicated in oncogenic processes and tumor metastasis upon uptake by recipient cells. To investigate the impact of EV biomarkers on tumorigenesis, we exposed HCT-116 cell lines to EVs isolated from the serum of both tumor patients and healthy individuals. In comparison to cell lines treated with extracellular vesicles (EVs) from healthy individuals and blank controls, cell lines treated with EVs from HCC sources exhibit significant alterations in the expression of certain genes associated with pathways related to liver cancer. Our findings shedlight on the intricate interplay between EVs and tumor progression.
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